IU Research Team makes huge ground in life-saving efforts against peanut allergies
Researchers from Indiana University School of Medicine have found a way to block anaphylaxis caused by peanut allergies.The groundbreaking discovery could lead to life-saving therapeutics for people with severe peanut allergies.
The team details their findings in a newly published article in Science Translational Medicine. When someone is allergic to a food, it is a result of allergen proteins cross-linking allergen specific immunoglobulin E (IgE) on the surface of mast cells and basophils. Activation of these cells can lead to anaphylaxis, a severe, life-threatening allergic reaction that can occur very quickly after exposure to an allergen.
Researchers developed peanut-specific inhibitors called covalent heterobivalent inhibitor (cHBI), that successfully blocked mast cell or basophil degranulation and anaphylaxis in an animal model.
The inhibitor has not been tested in human patients yet. Researchers are now doing further testing in animal models to evaluate efficacy and toxicity before moving to clinical trials.
Monroe County’s Most Wanted
Help local Law Enforcement find these individuals, wanted on assorted Felony charges:
IU Student and Carmel native to appear on Jeopardy
Television’s Jeopardy will be featuring Indiana University Senior Audrey Satchivi for a return visit. The Carmel, Indiana native will be on the new program format, High School Reunion, which brings back 27 contestants that had been on the Jeopardy Teen Tournament 4 years prior.
This 14-day special event airs Monday, February 20th until Thursday, March 9th on NBC TV (7:30pm), when these former teen contestants will reunite to face off for a $100,000 grand prize and a spot in the Jeorardy Tournament of Champions. The format consists of nine quarterfinal games, three semifinals, and a two-day, total point affair final.
Satchivi’s first round match-up will air Tuesday, February 28th, as she takes on Anish Maddipoti, a Junior at the University of Texas at Austin from Austin, Texas, and Lucas Miner, a Junior at Yale University in New Haven, Connecticut from Miami, Florida.
This Week in Hoosier History
1929 – Five men from Chicago were arrested in Indianapolis and questioned about their possible participation in the “St. Valentine’s Day Massacre” the day before. The suspects told police they were members of the Al Capone gang and “plenty of money and help would be down from Chicago” to get them released. To this day, no one has been charged with the murders.
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